Lee Ann Meriwether was born on May 27, 1935, in Los Angeles, California, and is the eldest daughter of Claudius Gregg Meriwether and Ethel Eve Mulligan. Three years later, her younger brother by the name of Don Brett Meriwether, was born.

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After the birth of their second child, the Meriwether’s moved to Phoenix, Arizona. Her family then moved to San Francisco, where she got her high school education from George Washington High School. As early as in high school, Lee was always encouraged to take up acting as a career. No one would have thought that it would become a reality in the years that followed.